AIM: To compare the clinical effects of the intravitreal injection of triamcinolone acetonide(TA)and lucentis(LU)for macular edema in retinal vein occlusion.

METHODS: Forty cases of retinal vein occlusion with macular edema were analyzed retrospectively, all the case's best corrected visual acuity(BCVA)≤0.6, fovea centralis thickness(CMT)≥250μm. All the eyes were treated with intravitreal injection of TA(22 cases, 4mg, 0.1mL)or LU(18 cases, 0.5mg, 0.05mL). The follow-up time was 1, 2wk, 1, 2, 3 and 6mo. BCVA and CMT were measured.

RESULTS:The two group's BCVA were significantly improved than preoperation. There were significant differences at each follow-up time compared with preoperation(P<0.05). The best BCVA after intravitreal injection of TA was showed at 1mo(logMAR=0.30±0.20), while the intravitreal injection of LU was 2mo(logMAR=0.21±0.10). The two group's CMT were significantly relieved than preoperation. There were significant differences at each follow-up time compared with preoperation(P<0.05). The best CMT after intravitreal injection of TA and LU were all showed at 2mo(TA CMT=274.45±141.81μm, LU CMT=225.83±22.86μm).The BCVA is negatively related with CMT. The BCVA and CMT had no statistical difference between the two groups.

CONCLUSION: Intravitreal injection of TA and LU in the treatment of macular edema in retinal vein occlusion can reduce macular edema and improve the visual activity. There is no significant difference between the two treatments.