方法：收集2012-04/05在我院准分子激光中心接受角膜屈光手术的近视眼患者76例152眼，用OPD Scan ARK-10000测量瞳孔直径6mm时角膜前表面和全眼球3～6阶总高阶像差(total higher-order aberrations，HOAs)、总彗差(total coma aberration，TC)、总三叶草(total trefoil aberration，TT)、总球差(total spherical aberration，TS)均方根值(root mean square，RMS)及三阶彗差(Z₃^-1，Z₃¹)、三叶草(Z₃^-3，Z₃³)、四阶球差(Z₄⁰)的Zernike系数，计算补偿因子(compensation factor，CF)。

结果：角膜球差均为正值，33眼(21.7%)全眼球差为负值； 角膜TC均方根值及Z₃^-1 ，Z₃¹小于全眼像差，补偿因子为负值； 角膜HOAs，TT，TS均方根值及Z₃^-3，Z₃³，Z₄⁰均高于全眼像差，补偿因子为正值。

结论：眼内高阶像差对角膜高阶像差主要表现为补偿作用； 眼内球差对角膜球差有补偿作用，可降低全眼球差； 眼内彗差、三叶草对角膜高阶像差的作用个体差异较大，可表现为部分补偿、过度补偿和叠加，其中彗差以叠加作用为主，三叶草以补偿作用为主。

METHODS: Seventy-six myopic patients(152 eyes)who received corneal refractive surgery from April to May in 2012 were included in this study. The HOAs of the anterior corneal surface and the total ocular HOAs(3-6 stage)ocular were measured using OPD Scan ARK-10 000. The root mean square values(RMS)of total HOAs, total coma(TC), total trefoil(TT)and total spherical aberration(TS)and Zernike terms of Z₃^-1, Z₃¹, Z₃^-3, Z₃³, Z₄⁰ of a pupil with a diameter of 6mm were recorded to calculate the compensation factor.

RESULTS: The corneal spherical aberration were positive in all eyes, but ocular spherical aberration were negative in 33 eyes(21.7%); The RMS values of corneal TC and Zernike terms of corneal Z₃^-1, Z₃¹ were smaller than the ocular aberration. and their CFs were negative; The RMS values of corneal HOAs, TT, TS and Zernike terms of corneal Z₃^-3, Z₃³, Z₄⁰ were higher than the ocular aberration and their CFs were positive.

CONCLUSION: Theintraocular HOAs mainly manifest compensation effect on the HOAs of the cornea; The intraocular spherical aberration compensates for the spherical aberration of cornea,which can reduce the ocular spherical aberration; The effects of intraocular coma and trefoil on corneal higher order aberrations vary widely and show partial compensation, overcompensation and superposition among subjects. The main role of coma is superposition, while that of trefoil mainly manifest as compensation action.