方法：应用Intralase飞秒激光和Amadeus Ⅱ微型角膜板层刀对65例屈光不正患者做角膜瓣，Intralase飞秒激光组和Amadeus Ⅱ微型角膜板层刀组分别按屈光度≤-3.00D为A组，-3.00结果：术后1mo，Intralase飞秒激光组达到或超过术前最佳矫正视力者(best corrected visual acuity，BCVA)60眼(93.8%)，Amadeus Ⅱ微型角膜板层刀达到或超过术前BCVA者61眼(92.4%)， 两组比较差异无统计学意义(P=0.421)。在不同屈光度分组中总像差、彗差、球差和三叶草差两组相比都没有显著差异。

结论：飞秒激光制瓣和微型角膜板层刀制瓣行LASIK术后视力、总像差、球差、彗差和三叶草差两组没有显著差异，都是安全有效的方法。

METHODS: Flap creation for LASIK was performed using IntraLase femtosecond laser(Intralase group)or Amadeus II microkeratome(Amadeus group)in 130 eyes with ametropia. Patients of Intralase group and Amadeus group were divided into three groups with different refractive degrees: ≤-3.00D was A, -3.00RESULTS: One month after LASIK, the postoperative vision of 60 eyes(93.7%)were the same as or better than preoperative BCVA in Intralase group and the postoperative vision of 61 eyes(92.4%)were the same as or better than preoperative BSCVA in Amadeus group. There was no significant difference between two groups(P=0.421). There was no significant difference in RMS values, spherical aberration, coma and trefoil between the groups in refractive degrees.

CONCLUSION: There is no significant difference in postoperative vision, RMS values, spherical aberration, coma and trefoil between Intralase femtosecond laser group and Amadeus Ⅱ microkeratome group. Both methods are effective and safe.