AIM: To investigate the effects of photocoagulation with 577-nm laser combined with calcium dobesilate on diabetic retinopathy(DR).

METHODS: From January 2012 to June 2012, 104 patients(180 eyes)with diabetic retinopathy were selected and randomly divided into medicine group, 577-nm laser group and combined treatment group. The medicine group consisting of 32 cases(56 eyes)received calcium dobesilate, and 577-nm laser group including 50 cases(86 eyes)were treated by photocoagulation with 577-nm laser. And 22 cases(38 eyes)of combined treatment group were treated with both methods above. The follow-up period was 6mo. The effects were evaluated by visual acuity and fundus fluorescein angiography(FFA).

RESULTS: Compared with medicine group, the rate of disappeared retinal capillary nonperfusion areas and regressed neovascularization was higher in 577-nm laser group. And the visual acuity of 577-nm laser group was improved significantly more than the medicine group. The difference was statistically significant(P<0.05). The combined treatment group achieved more favorable results than every single treatment group(P<0.05).

CONCLUSION: Photocoagulation with 577-nm laser combined with calcium dobesilate is effective for diabetic retinopathy and it is worth making more application in clinic.