AIM: To discuss the drug resistance and sensitivity of broad-spectrum antibiotics about the pathogens that resulting in infectious endophthalmitis.

METHODS: The vitreous bodies of 15 patients were extracted in our hospital during the operation of infectious endophthalmitis after their cataract operation and then did the etiological examination and analyzed the results.

RESULTS: The anterior chamber aqueous and vitreous bodies of the 15 patients were collected during the operation and did the bacterial culturing and drug sensitivity tests. Seven of the 15 cultured pathogenic bacteria. Positive rate of the bacterial culture was 46%(1 fungus, 3 staphylococcus epidermidis, 1 staphylococcus lentus, 1 coagulase negative staphylococcus, 1 aerococcus viridians). Eight of the 15 didn't culture any bacteria. Three staphylococcus epidermidis and 1 staphylococcus lentus among the positive cases showed resistance to levofloxacin in the drug sensitivity test and the MIC were all more than 4. In addition 1 coagulase negative staphylococcus and 1 aerococcus viridians showed sensitivity to levofloxacin and the MIC were all less than 2. Vancomycin and rifampicin were sensitive antibiotics and the MIC were all less than 1.

CONCLUSION: Most medical institution use levofloxacin as the prophylactic therapy routinely in inner eye operation, but this article questions this phenomenon. It's common that clinicians use drugs to resist pathogens by their experiences. When pathogens show drug resistance, empirical medication will lead to worse treatment effect or even much worse consequence without bacterial culturing and drug sensitivity tests. So it's right to choose the antibiotics according to the results of the bacterial culturing and drug sensitivity tests properly and timely. It's the first choice of standard treatments to adjust the therapeutic regimens timely.