方法：将符合干眼症诊断标准的150例300眼机分为治疗组和对照组，各75例150眼。治疗组采用局部滴用小牛血清去蛋白提取物眼用凝胶和右旋糖酐羟丙纤维素滴眼液治疗； 对照组采用单纯滴用右旋糖酐羟丙纤维素滴眼液治疗。根据临床症状和基础泪液分泌试验、泪膜破裂时间、角膜荧光素钠染色等检查进行评分，以及泪液蛋白进行测定，治疗观察3mo。

结果：两组治疗后泪膜破裂时间(breaking up time，BUT)， 基础泪液分泌试验(SchirmerⅠ test，SⅠt)，角膜荧光素染色与治疗前比较，差异均有统计学意义(P<0.05或P<0.01)，且治疗后治疗组上述指标变化程度明显优于对照组(P<0.05)； 治疗组总有效率96%，对照组总有效率75%，治疗组疗效明显优于对照组(P<0.05)。治疗组治疗后泪液蛋白含量明显提高(P<0.05)。

结论：小牛血清去蛋白提取物眼用凝胶联合人工泪液局部点眼治疗干眼症疗效较单纯使用人工泪液滴眼疗效好。

METHODS: A randomized, parallel-control approach was adopted, 150 patients(300 eyes)with dry eye were divided into treatment group and control group equally(75 cases, 150 eyes). The treatment group was applied Dextran and Hypromellose eye drops combined with deproteinated extract of calf blood ophthalmic gel, simply Dextran and Hypromellose eye drops for control group. Clinical symptoms, SchirmerⅠ test(SⅠt), break-up time(BUT), corneal fluorescein staining and tear protein were observed. Therapeutic observation was 3mo.

RESULTS: BUT, SⅠt, and corneal fluorescein staining have statistical significance before and after treatment(P<0.05 or P<0.01), the changes in treatment group were obviously superior to that in control group(P<0.05). The total clinical effect satisfaction rates were 96% for treatment group and 75% for control group, curative effect in treatment group was obviously superior to control group(P<0.05). Tear protein was significantly improved in treatment group(P<0.05).

CONCLUSION: The deproteinated extract of calf blood ophthalmic gel with artificial tears local eye drops perform better than artificial tears eye drops only in treatment of dry eye.