AIM: To observe the efficacy of high concentrations of sodium hyaluronate(3g/L SH)for moderate to severe dry eye.

METHODS: Forty moderate to severe dry eye patients were included in the study according to the diagnosis criteria and randomized into two groups. The patients of the trial group received topical administration of high concentration sodium hyaluronate(3g/L), and those of the control group received sodium hyaluronate(1g/L)plus recombinant human epidermal growth factor. The dry eye symptom scores, ocular surface disease index(OSDI)scores, tear film break-up time(BUT), Schirmer Ⅰ test and corneal fluorescein staining score were evaluated.All the indexes were compared between the two groups 2wk before and after treatment.

RESULTS: There were no significant differences of the indicators between the two groups before treatment. After 2wk treatment, the differences were statistically significant compared to former except for the Schirmer Ⅰ test. Compared with the control group, the symptom scores and the OSDI scores were lowered. No significant differences were found in the other indicators between these two groups.

CONCLUSION: Topical usage of highconcentrations of sodium hyaluronate(3g/L)is beneficial for remitting the ocular symptoms in moderate to severe dry eyes, and also improve the quality of life of patients.