AIM: To observe the efficacy of using botulinum toxin A in the treatment of blepharospasm.

METHODS:Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated.

RESULTS:Fifty-nine cases(52.2%)had a complete remission of symptoms, 49 patients(43.4%)presented with obvious relieved spasm, 4 cases(3.5%)were partially relieved and the 1 patient(0.9%)remained unchanged. The total effective rate was 99.1%. The time of beginning effect was 1-14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1-9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk.

CONCLUSION:Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.