方法：选取本院眼科门诊诊断明确的眼睑痉挛的患者113例，采用A型肉毒毒素局部注射治疗，并对治疗疗效进行评估。

结果：患者59例(52.2%)症状完全缓解，49例(43.4%)明显改善，4例(3.5%)部分改善，1例无效(0.9%)，总有效率达到99.1%。起效时间1～14d，大多于14d内达到最佳效果，疗效持续1～9mo。不良反应可出现轻度眼睑闭合不全、上睑下垂、局部皮下瘀血等共23例，均在2～4wk内恢复。

结论：局部注射A型肉毒毒素治疗中重度眼睑痉挛安全、有效。

METHODS:Totally 113 patients with blepharospasm were managed with a local injection of botulinum toxin A, and the therapeutic effect was evaluated.

RESULTS:Fifty-nine cases(52.2%)had a complete remission of symptoms, 49 patients(43.4%)presented with obvious relieved spasm, 4 cases(3.5%)were partially relieved and the 1 patient(0.9%)remained unchanged. The total effective rate was 99.1%. The time of beginning effect was 1-14d. The recover time was mostly in 14d. The average of therapeutic effect lasted 1-9mo. Adverse reactions such as mild palpebra dysraphism, palpebra ptosis and local subcutaneous blood stasis were found in 23 patients, and the symptoms disappeared in 2-4wk.

CONCLUSION:Botulinum toxin A can effectively control medium and severe blepharospasm by injecting a little dose on local muscle.