AIM:To investigate the effect of compound anisodine on fundus blood circulation after vitrectomy with face-down position.

METHODS: Sixty patients(60 eyes)with rhegmatogenous retinal detachment received vitrectomy with silicone oil tamponade operation, who were randomized divided into treatment group(30 eyes)and control group(30 eyes). The patients in the treatment group received the subcutaneously injection of compound anisodine hydrobromide by the superficial temporal artery once daily for 14d since postoperative first day. Retinal microcirculation blood flow parameters were recorded with Heidelberg retinal flowmeter postoperative 1d, 1 and 2wk, and were compared between two groups.

RESULTS: The blood flow parameters(Vol, Flw, Vel)of control group postoperative 1 and 2wk were significantly less than those postoperative 1d. Otherwise the parameters of treatment postoperative 1 and 2wk were significantly more than those postoperative 1d. The parameters between two groups were significant different(P<0.01).

CONCLUSION: Facing down after vitrectomy with silicone oil tamponade may reduce retinal blood supply, consequently lead to retinal ischemia; compound anisodine can effectively improve the retinal and choroidal microcirculation after vitrectomy with face-down posture, reduce retinal ischemia, and enhance the visual function.