AIM: To evaluate the diagnostic accuracy of macular ganglion cell-inner plexiform layer(GCIPL)measurements using high-definition optical coherence tomography(Cirrus HD-OCT)ganglion cell analysis algorithm for detecting early and moderate to severe glaucoma.

METHODS:Twenty normal control persons, 26 patients with early glaucoma and 29 patients with moderate to severe glaucoma were enrolled in this study. Macular GCIPL, optic nerve head(ONH)parameters and peripapillary retinal nerve fiber layer(RNFL)thickness were measured in each subject. Then all measured results of each parameter were calculated using SPSS17.0. Areas under the receiver operating characteristic curves(AUC)of each parameter were calculated to compare the diagnostic accuracy for detecting early and moderate to severe glaucoma.

RESULTS:For detecting early glaucoma, AUC of average RNFL and seven clock value of RNFL were the biggest(0.871 and 0.896 respectively), the AUC of parameters in GCIPL were also significant, among them, the average GCIPL showed bigger AUC(0.847)than the minimum GCIPL(0.812). For diagnosing moderate to severe glaucoma, the AUC of rim area was 0.992, which was bigger than that of average RNFL(0.991). The minimum GCIPL showed bigger AUC(0.983)than the average GCIPL(0.967). For early glaucoma diagnosis, the sensitivity of average RNFL was the highest(76.9%), while the average GCIPL has the highest specificity(93.5%).

CONCLUSION:AS a new diagnostic parameter for detecting glaucoma, GCIPL shows similar diagnostic potential compared with RNFL. For early glaucoma diagnosis, average RNFL is the most important parameter, while screening early glaucoma, average GCIPL should be paid more attention.