方法：选取2012-05/2013-04期间我院收治的48例水液缺乏型干眼症患者为研究对象，进行Smart Plug泪小管塞治疗，观察术后临床疗效、基础泪液分泌试验(Schirmer Ⅰ test，SⅠt)、泪膜破裂时间(tear break up time，BUT)、角膜荧光素染色(fluoreseein staining，FL)变化。

结果：本组48例患者，显效31例(65%)，有效14例(29%)，无效3例(6%)，总有效率为94%。治疗前，患者SⅠt，BUT，FL分别为3.49±1.24mm/5min，3.15±1.07s，2.52±0.11分。治疗后，患者SⅠt，BUT，FL均明显改善，与治疗前比较，差异具有统计学意义(P<0.05)。1例患者术后有异物感，8h后栓子脱落； 1例患者于术后8mo出现肉芽组织，泪小管塞脱落。其余病例无下泪小管感染或肉芽肿。

结论：Smart Plug泪小管塞治疗水液缺乏型干眼症疗效确切，能够有效缓解临床症状，值得临床推广。

METHODS: Forty-eight cases of aqueous-deficient dry eye patients in our hospital from May 2012 to April 2013 were selected for the study. After treated by Smart Plug canalicular plug, postoperative clinical efficacy, foundation Schirmer I test(SIt), tear film break-up time(BUT), corneal fluorescein staining(FL)changes were observed.

RESULTS: Forty-eight patients were cured, 31 cases were markedly effective(65%), effective 14 cases(29%), invalid in 3 cases(6%), the total effective rate was 94%. Before treatment, SⅠt, BUT, and FL was(3.49±1.24)mm/5min,(3.15±1.07)s, and(2.52±0.11)points, respectively. After treatment, SIt, BUT, FL were significantly improved compared with before treatment, the difference was statistically significant(P<0.05). One patient had postoperative foreign body sensation, 8h after shedding emboli; One patient granulation tissue after surgery 8mo, canalicular plug off. The remaining cases had no inferior lacrimal duct infection or granuloma.

CONCLUSION:Smart Plug canalicular plug is an effective treatment for aqueous-deficient dry eye, can effectively relieve symptoms, worthy of promotion.