AIM:To estimate the clinical significance of the microculture of humor and vitreous and vancomycin intraocular injection in treatment of suppurative endophthalmitis associated with intraocular foreign bodies.

METHODS: Totally 65 patients with penetrating eye trauma and retained intraocular foreign bodies in emergency operation and intraocular injection from January 2012 to September 2014 were regarded as the study group, another 62 patients with penetrating eye trauma and retained intraocular foreign bodies in emergency operation without intraocular injection before August 2011 were regarded as the control group. Aqueous humor and vitreous humor were taken from each patient of the study group and the control group for bacteria and fungus cultivation. The study group was treated with 1mg vancomycin intraocular injection after operation, while the control group was not.

RESULTS: The incidence of endophthalmitis in the control group was 16%(10 cases), while in the study group was 3%(2 cases), with significant difference between two groups(x²=6.32, P<0.05). The aqueous humor germiculture in both groups was in low positive rates, the study group was 3%(2 cases)and the control group was 2%(1 case), with no difference between two groups(P>0.05). The positive rate of vitreous humor germiculture in study group was 14%(9 cases), and the incidence of endophthalmitis was 3%. The positive rate of vitreous humor germiculture in control group was 11%(7 cases)and the incidence of endophthalmitis was 16%, with significant differences between two groups(P<0.05).

CONCLUSION: Intraocular foreign bodies treated with emergency operation and vancomycin intraocular injections can decrease the incidence of suppurative endophthalmitis and have a good vision prognosis for the second stage of operation.