Age-related macular degeneration(AMD)is a chronic progressive macular disease that occurs mostly in people over the age of 50, which is the main eye disease that causes loss of vision in the elderly in developed countries. Along with coming of aging population in our country, the incidence of AMD is increasing, but its pathogenesis is still unclear, the latest research shows that eye tissues are with independent synthetic renin-angiotensin system(RAS)capabilities, besides numbers of studies have shown that the RAS in early and late AMD were directly involved in the disease development and played an important role in the pathogenesis, this paper gives a brief review of research progress on mechanism of RAS in AMD.