方法：选取我院2014-08/10近视患者28例56眼 ，等效球镜-3.83±1.19D。釆用Sirius系统测量戴镜前、戴镜1d； 1wk； 3mo后的中央角膜厚度(center cornea thickness， CCT)、前房深度(anterior chamber depth， ACD)及角膜前表面曲率(anterior K，a-K)、角膜后表面曲率(posterior K，p-K)。

结果：所有患者在配戴角膜塑形镜后1wk均达到矫正效果。CCT及p-K各时间点间两两比较均无统计学差异(P>0.05)； a-K除戴镜1wk与戴镜3mo之间无统计学差异外，其余各时间点间两两比较均有统计学差异(P<0.05)； ACD在戴镜1wk与戴镜前、戴镜3mo与戴镜1d及戴镜1wk之间比较均有统计学差异(P<0.05)。Pearson相关性分析显示戴镜前CCT(CCTpre)与戴镜3mo后CCT的变化值(CCT-3mo-change，CCTc-3mo)显著相关(P<0.05)； ACDpre与ACDc-1d显著相关(P<0.05)； a-Kpre与a-Kc-1d，a-Kc-1wk，a-Kc-3mo均显著相关(P<0.05)。多元线性回归分析显示a-Kc-1d(P=0.016)、a-Kc-1wk(P=0.047)与a-Kpre及眼轴显著相关； a-Kc-3mon与a-Kpre显著相关(P=0.024)； ACDc-1d与ACDpre显著相关(P=0.036)； CCTc-3mo与CCTpre显著相关(P=0.012)。

结论：sirius测量的角膜塑形术后CCT，ACD及p-K的变化并不明显，而a-K明显改变，它可能是角膜塑形效果的关键因素之一。Sirius 眼前节分析系统用于角膜塑形术术前检查及术后评估，无创、可靠，具有很好的临床应用价值。

METHODS: Twenty-eight patients(56 eyes)with myopia in our hospital from August 2014 to October 2014 were included. Spherical equivalent were -3.83±1.19D. Data of central corneal thickness(CCT), anterior chamber depth(ACD), anterior corneal curvature(a-K)and posterior corneal curvature(p-K)were collected and analyzed at before, 1d, 1wk and 3mo after orthokeratology.

RESULTS: After orthokeratology, spherical equivalent of all eyes decreased to predicted level. There were no significant differences in CCT and p-K between different times(P>0.05). There were significant differences in a-K between different times except between 1wk and 3mo after orthokeratology(P<0.05). There were significant differences in ACD between before and 1wk after, between 1d and 3mo after, between 1wk and 3mo after orthokeratology(P<0.05). There were correlations between CCT before orthokeratology(CCTpre)and the change at 3mo after orthokeratology(CCTc-3mo), between ACD before orthokeratology(ACDpre)and the change at 1d after orthokeratology(ACDc-1d), between a-K before orthokeratology(a-Kpre)and the changes at 1d(a-Kc-1d), 1wk(a-Kc-1wk)and 3mo(a-Kc-3mo)after, respectively(all P<0.05). Multiple linear regression suggested that a-Kc-1d(P=0.016), a-Kc-1wk(P=0.047)were correlated with a-Kpre and axial, respectively. And there were correlations between a-Kpre and a-Kc-3mo(P=0.024), between ACDpre and ACDc-1d(P=0.036), between CCTpre and CCTc-3mo(P=0.012), respectively.

CONCLUSION: CCT, ACD and p-K has no significant changes after orthokeratology, while there is significant difference in a-K, which is considered one of the most key factor in orthokeratology. Sirius anterior system for examination before orthokeratology and postoperative assessment, non-invasive, reliable and has a good clinical value.