方法：采用病例对照研究及Meta分析。连续的CSCR患者46例纳入研究，CSCR患者散瞳后前置镜眼底检查，荧光素眼底血管造影和吲哚菁绿血管造影检查确诊。选择同期年龄、性别、屈光度及眼轴匹配的正常人62例62眼作为正常对照组。用加强成像深度扫描OCT检测并比较CSCR组及对照组SFCT。单因素和多因素分析SFCT与各临床资料之间的关系。Meta分析用Stata软件计算两组之间的加权均数差。

结果：CSCR患者的平均SFCT为397.34±83.91μm，正常对照组为274.48±62.57μm。CSCR组SFCT较对照组明显增厚，差异有统计学意义(P<0.01)。单因素与多因素线性回归分析，SFCT与CSCR诊断显著相关。Meta分析结果：CSCR组的黄斑中央凹下脉络膜较正常组厚，加权平均差异为156.13μm(95% CI： 137.43， 174.83)。

结论：CSCR患者黄斑中央凹下脉络膜较正常眼厚，增厚的SFCT与CSCR诊断存在相关性。

METHODS: This was a case-control study and a Meta-analysis. Forty-six CSCR patients diagnosed by the fundus pre-set lens, fundus fluorescein angiography(FFA)and indocyanine green angiography(ICGA)were enrolled in this study. Sixty two age-, sex-, diopter- and axial length-matched 62 normal subjects(62 eyes)were enrolled in this study as the control group. Using enhanced depth imaging optical coherence tomography(EDI-OCT), SFCT of CSCR eyes and normal control eyes were measured and compared. Univariate and multivariate linear regression analysis were performed to assess the association between SFCT and clinical factors. The Meta-analysis were conducted using the Stata software package to calculate the summary weighted mean differences(WMDs).

RESULTS:The mean SFCT of the CSCR group and the normal control group was 397.34±83.91μm and 274.48±62.57μm, respectively. The CSCR eyes had a thicker choroid than the control eyes at the SFCT(P<0.01). Univariate and multivariable linear regression analysis showed that the SFCT was significantly thicker in association with the CSCR diagnosis. The result of our case-control study was consistent with the results of the further Meta-analysis with the pooled WMD of 156.13μm(95% CI: 137.43, 174.83)for SFCT.

CONCLUSION:Along with the comprehensive Meta-analysis, SFCT in CSCR eyes was thicker than that of normal control eyes. Increased SFCT might be associated with CSCR.