AIM:To investigate the changes of subfoveal choroidal thickness(SFCT)in central serous chorioretinopathy(CSCR)eyes and to compare them with normal control eyes.

METHODS: This was a case-control study and a Meta-analysis. Forty-six CSCR patients diagnosed by the fundus pre-set lens, fundus fluorescein angiography(FFA)and indocyanine green angiography(ICGA)were enrolled in this study. Sixty two age-, sex-, diopter- and axial length-matched 62 normal subjects(62 eyes)were enrolled in this study as the control group. Using enhanced depth imaging optical coherence tomography(EDI-OCT), SFCT of CSCR eyes and normal control eyes were measured and compared. Univariate and multivariate linear regression analysis were performed to assess the association between SFCT and clinical factors. The Meta-analysis were conducted using the Stata software package to calculate the summary weighted mean differences(WMDs).

RESULTS:The mean SFCT of the CSCR group and the normal control group was 397.34±83.91μm and 274.48±62.57μm, respectively. The CSCR eyes had a thicker choroid than the control eyes at the SFCT(P<0.01). Univariate and multivariable linear regression analysis showed that the SFCT was significantly thicker in association with the CSCR diagnosis. The result of our case-control study was consistent with the results of the further Meta-analysis with the pooled WMD of 156.13μm(95% CI: 137.43, 174.83)for SFCT.

CONCLUSION:Along with the comprehensive Meta-analysis, SFCT in CSCR eyes was thicker than that of normal control eyes. Increased SFCT might be associated with CSCR.