AIM:To evaluate the morphological changes of peripapillary atrophy(PPA)and retinal thickness(RT)in high myopia under different best corrected visual acuity(BCVA).

METHODS: A retrospective review of medical records in 55 high myopia patients(104 eyes)was carried out, whose spherical equivalent(SE)refractive errors ranged from -6～-27D. Groups A, B and C were divided according to different BCVA. The parameters including optic disc(OD)size, PPA size, the biggest width of OD along the horizontal axis, the biggest width of PPA along the horizontal axis, the size of the peripapillary chorioretinal atrophy(PCA), the average 6mm center retinal thickness(ACRT), the center retinal thickness(CRT), the total 6mm center retinal volume(TCRV)were evaluated. All the data were analyzed respectively by one-way ANOVA with edition SPSS 13.0.

RESULTS: There were significant differences among three groups on PPA size(8.29±4.82, 4.31±3.05, 2.49±2.60mm² in groups A, B and C, respectively), PPA width(1.88±0.83, 1.31±0.66, 0.86±0.61mm in groups A, B and C, respectively)(all P<0.01). The PCA size was increased significantly in group A(4.26±4.27mm²)than other groups(group B: 1.23±1.74mm², group C: 0.62±1.53mm²)(F=19.58, P<0.01). The OD size and width had no significant differences among three groups(F=1.1, P=0.33; F=0.44, P=0.64). ACRT and TCRV reduced significantly in group A(ACRT: 211.34±118.32μm; TCRV: 6.09±3.65mm³)than in other groups(F=4.28, P=0.01; F=3.35, P=0.03), but no significant difference between groups B and C. CRT was not changed in three groups(F=2.23, P=0.11).

CONCLUSION: PCA increase, ACRT and TCRV decrease assist to evaluate visual function in high myopia. PPA increase indicates the myopia progress.