Retinal angiomatous proliferation(RAP)is a special type of wet age-related macular degeneration(AMD)and is classified into stages Ⅰ～Ⅲ by clinical manifestations, the form of neovascularization at the end stage. Differed with several types of neovascular AMD, the neovascularizations in RAP are believed to originate from the inner retinal capillary network. At present, it is controversial that RAP and wet AMD are different subtypes of the same disease or two independent diseases. Clinical differential diagnosis of the two diseases are important because of their different nature history, prognosis and treatments. In recent years, the identification of RAP and wet AMD has made significant progress with new technology application, such as the indocyanine green angiography(ICGA)and optical coherence tomography(OCT). In this paper, the clinical manifestations, natural history, treatments and prognosis of the two diseases were reviewed.