AIM: To observethe changes of visual evoked potential(VEP)of optic nerve contusion treated with mouse nerve growth factor and estimate the efficacy of mouse nerve growth factor.

METHODS: Thirty-four cases(34 eyes)of optic nerve contusion enrolled from October 2013 to February 2015 were selected and randomly divided into two groups. The treatment group 22 patients(22 eyes)was given the mouse nerve growth factor 30μg, with 2.0mL dissolved in water for injection, intramuscular injection once daily, with an average treatment of 42d, while for the hormones and vitamins medication treatment. For the control group 12 cases(12 eyes), mouse nerve growth factor was not used, other drugs were the same as the treatment group. All patients were accepted a review of vision and VEP at 21, 42d after the treatment.

RESULTS: After 42d treatment, the difference of best corrected visual acuity showed statistical significance(P<0.05)and VEP P100 latent period was 104.59±7.54ms, amplitude was 5.12±1.48μV in treatment group. While, latent period was 113.25±9.21ms, amplitude was 4.69±1.89μV in control group. Also, VEP P100 latency of the two groups showed statistical significance(t=-3.132, P<0.05)after 42d treatment, while VEP P100 amplitude had the same conclusion(t=2.541, P<0.05). The effective rate was 82% in treatment group, while 42% in control group with significant difference(P=0.026).

CONCLUSION: Mouse nerve growth factor has significant efficacy on traumatic optic nerve contusion, the changes of VEP can accurately reflect the conclusion, and VEP has proved to be an important basis on estimating the clinical efficacy.