Heat shock protein(HSP)is a kind of heat stress protein that widely exists in organism. Its expression will be significantly increased if the cells are under stress conditions(such as heat shock, pathogen infection, tissue injury, physiological stress, etc.). HSP60 is one of the families of HSPs, which can be induced by various stimuli, and may be released by stress or necrotic cells. HSP60 could play an important role in anti-infection, autoimmune, aging and apoptosis. The latest researches showed that HSP60 involved in the pathogenesis of a variety of eye diseases. Therefore, the effect and of HSP60 on the eyes and its molecular mechanism in related disease processes were reviewed in this study.