AIM: To observe the clinical efficacy of internal limiting membrane(ILM)peeling combined silicone oil removal and filled with C₃F₈ on silicone oil-filled eye with submacular fluid.

METHODS: Thirty-one patients(31 eyes)with persistent submacular fluid after pars plana vitrectomy combined with silicone oil filled in our hospital from January 2007 to December 2013. According to operation mode, those patients were divided into group A(silicone oil removal)and group B(ILM peeling combined silicone oil removal and C₃F₈ filled).Follow-up time after surgery was 6～12(mean 8.33±1.45)mo. The LogMAR best-corrected visual acuity(BCVA)and the neuroepithelial thickness of macular fovea was observed at postoperative 3, 6mo.

RESULTS: Postoperative 3mo LogMAR BCVA was improved in each group compared to preoperative LogMAR BCVA, the difference was significant(t=2.326, 2.577, P<0.05). the difference on LogMAR BCVA improvement rate of group A and B had statistical significance(χ²=5.473, P<0.05). Postoperative 6mo LogMAR BCVA was improved in each group compared to preoperative LogMAR BCVA, the difference was significant(t=4.216, 3.801; P<0.05). The difference on LogMAR BCVA improvement rate of group A and B had significance(χ²=4.210, P<0.05). Postoperative the neuroepithelial thickness of macular fovea was decreased in each group compared to that of preoperative

CONCLUSION: ILM peeling combined silicone oil removal and C₃F₈ filled is an effective method in treatment of silicone oil-filled eye with persistent submacular fluid.