AIM:To observe thickness and morphological changes of cornea and bulbar conjunctiva pre- and post acute angle closure glaucoma(AACG)therapy by optical coherence tomography(OCT).

METHODS:Twenty-five patients with AACG were recruited. Intraocular pressure(IOP)and morphological characteristic of cornea and conjunctiva were measured at their first visit, 1, 2 and 3d after they began the treatments.

RESULTS:The corneal epithelium thickness and corneal thickness of patients with acute attack of angle closure glaucoma were 72.76±11.95μm and 589.40±66.91μm; the conjunctival epithelial layer thickness was 58.88±12.87μm; the thickness of conjunctive stroma was 299.76±94.86μm; the conjunctival full thickness was 358.64±102.55μm. The corneal epithelium thickness and corneal thickness at the first day of the treatment were 69.28±12.65μm and 579.04±67.88μm; the conjunctival epithelial layer thickness was 57.04±12.05μm; the thickness of conjunctive stroma was 282.44±91.47μm; the conjunctival full thickness was 339.48±100.28μm. the corneal epithelium thickness and corneal thickness at the second day of treatment were 66.76±11.42μm and 563.32±63.87μm; the conjunctival epithelial layer thickness was 54.76±11.01μm; the thickness of conjunctive stroma was 267.00±98.54μm; the conjunctival full thickness was 322.16±106.12μm. the corneal epithelium thickness and corneal thickness of the third day treatment are 65.16±12.25μm and 550.36±71.48μm; the conjunctival epithelial layer thickness was measured 53.36±10.29μm; the thickness of conjunctive stroma was 252.76±99.32μm; the conjunctival full thickness was 306.52±107.31μm. The difference of IOP, corneal epithelial thickness, corneal thickness, conjunctival epithelial layer thickness, conjunctival stroma thickness and conjunvtival full thickness had statistically significant(P<0.05).

CONCLUSION:The corneal and conjunctival thickness in patients at acute attack of angle closure glaucom increase. The edema level decreases with IOP.