方法：行白内障超声乳化联合人工晶状体植入术的老年性白内障患者100例120眼，将患者随机分为两组：0.1%溴芬酸钠水合物滴眼液和妥布霉素地塞米松滴眼液联合用药组(试验组)、术后单独滴用妥布霉素地塞米松滴眼液组(对照组)。手术方法采用巩膜隧道切口超声乳化白内障摘除联合人工晶状体植入术。术后第1、7、14d观察症状和体征并进行评分； 并观察眼压变化及黄斑水肿发生情况。

结果：患者100例120眼完成研究，两组患者症状和体征综合评分术后1d无统计学差异(P>0.05)，而术后7、14d内有统计学差异(P<0.05)，试验组比对照组值低。术前眼压试验组(14.657±2.605mmHg)和对照组(14.415±2.761mmHg)比较，差异无统计学意义(P>0.05)。试验组眼压：在术后1、7、14d眼压均低于对照组，差异有统计学意义(P<0.05)。黄斑水肿发生率：对照组术后1、7、14d黄斑水肿发生率分别为1.7%、1.7%和3.3%，明显高于试验组的 0、0和1.7%，两组比较差异具有统计学意义(P<0.05)。

结论：应用0.1%溴芬酸钠水合物滴眼液和妥布霉素地塞米松滴眼液对白内障超声乳化摘除联合人工晶状体植入术后炎症的治疗效果较佳，是安全有效的，且不易发生高眼压等严重并发症； 同时可显著降低术后黄斑水肿发生率，预防白内障术后黄斑水肿的发生，具有安全可靠性，值得临床推广应用。

METHODS:A prospective, randomized, controlled study including 100 patients(120 eyes), enrolled for cataract surgery. The patients were randomized to topical treatment with Tobramycin and Dexamethasone combined with bromfenac sodium 0.1%(trial group, 60 eyes)or Tobramycin and Dexamethasone(control group, 60 eyes). Scleral tunnel incision phacoemulsification cataract extraction and intraocular lens implantation was used. The sign, symptom, intraocular pressure(IOP)and optical coherence tomography(OCT)were determined postoperative 1, 7, 14d.

RESULTS:There were significant differences in symptoms and signs between two groups at postoperative 7 and 14d(P<0.05)and no difference at postoperative 1d(P>0.05). The value of the trial group was lower than that of the control group. Preoperative IOP was 14.657±2.605mmHg in trial group and 14.415±2.761mmHg in control group, the difference was not statistically significant(P>0.05). IOP in trial group were lower than that of control group at postoperative 1, 7, 14d, the difference was statistically significant(P<0.05). In the control group, the incidence of macular edema at postoperative 1, 7, 14d were 1.7%, 1.7% and 3.3%, respectively, which was significantly higher than those of trial group(0, 0, 1.7%). The difference was statistically significant(P<0.05).

CONCLUSION:Application of 0.1% bromfenac sodium eye drop and Tobramycin and Dexamethasone eye drops for cataract extraction and intraocular lens implantation in the treatment of postoperative inflammation has better treatment effect. It is safe and effective, and less prone to ocular hypertension and other serious complications; At the same time it can significantly reduce the incidence of postoperative macular edema, prevention of macular edema after cataract surgery, with security and reliability, worthy of clinical application.