方法：选取我院2013-01/2015-06收治的40例原发性开角型青光眼患者为观察组，同期我院患者家属40例为对照组。监测受试者24h的眼压、血压与眼灌注压的昼夜波动情况，得出收缩期眼灌注压(SOPP)、舒张期眼灌注压(DOPP)和平均眼灌注压(MOPP)。采用Pearson线性相关性分析MOPP昼夜波动与杯盘比、视野平均缺失(MD)及图形标准差(PSD)的相关性。

结果：观察组患者全天和夜间的MOPP、SOPP和DOPP波动均大于对照组(P<0.05)。MOPP 昼夜波动与MD存在显著的负相关(r=-0.389，95%CI：-0.612～-0.082； P=0.011)； 与PSD呈正相关(r=0.512，95%CI：0.139～0.782； P=0.008)； 与垂直杯盘比之间无相关性(r=0.115，95%CI：0.056～0.369； P=0.355)。

结论：原发性开角型青光眼患者眼灌注压波动可反映病情的严重程度，可能会导致疾病向严重方向发展，因此通过行24h的灌注压的监测可帮助我们了解原发性开角型青光眼患者全天的眼部血流状态，了解病情发展。

METHODS:Forty patients with primary open angle glaucoma from January 2013 to June 2015 in our hospital were used as observation group and 40 families were used as control group. Circadian fluctuation of intraocular pressure, blood pressure and ocular perfusion pressure in 24h were determined to obtain systolic ocular perfusion pressure(SOPP), diastolic ocular perfusion pressure(DOPP)and mean ocular perfusion pressure(MOPP). Pearson linear correlation was used to analyze the correlation of circadian MOPP fluctuation with cup-disc ratio, mean defect(MD)and the picture standard deviation(PSD).

RESULTS:The fluctuation of MOPP, SOPP and DOPP of observation group were significantly higher than those of control group(P<0.05). MOPP fluctuation was negatively correlated with MD(r=-0.389, 95%CI:-0.612～-0.082; P=0.011), was positively correlated with PSD(r=0.512, 95%CI:0.139 ～0.782; P=0.008); no correlation was found between it and the vertical cup-disc ratio(r=0.115, 95%CI:0.056～0.369; P=0.355).

CONCLUSION:Ocular perfusion pressure fluctuations in patients with primary open angle glaucoma may reflect the severity of the disease and may make the situation aggravating. Therefore through perfusion pressure monitor in 24h may help us understand the ocular blood flow and the development of primary open-angle glaucoma.