方法：选择2010-01/2015-01我院诊治的蒸发过强型干眼患者39例65眼为研究对象。另取健康体检者30例53眼为对照组，对所有患者进行抗炎药物治疗。治疗前测定两组泪液TNF-α、IL-1、IL-6、IL-8水平进行组间比较，并于治疗后1、4、10wk检测试验组上述各炎性因子水平进行组内比较。

结果：对照组的泪液TNF-α、IL-1、IL-6、IL-8水平均显著低于试验组，差异具有统计学意义(P<0.05)。治疗后1、4、10wk时观察指标评价结果存在统计学意义(P<0.05)，提示随着治疗时间的延长，患者各项观察指标均逐渐朝向正常值方向变化。治疗后1、4、10wk患者泪液TNF-α、IL-1、IL-6、IL-8比较存在统计学差异，上述各项指标均呈逐渐下降趋势，具有统计学差异(P<0.05)。

结论：TNF-α、IL-1、IL-6、IL-8在蒸发过强型干眼症患者中特异性升高，可作与疾病的发生发展密切相关，可作为临床诊断或疗效监测的重要参考指标。

METHODS:Thirty-nine patients(65 eyes)with evaporative dry eye treated from January 2010 to January 2015 in our hospital were selected as test group. Thirty healthy check-ups(53 eyes)were selected as control group. All the patients took the anti-inflammatory drugs. Before treatments, the levels of TNF-α, IL-1, IL-6, IL-8 of two groups was compared. After 1, 4 and 10w of treatments, the levels of inflammatory cytokines of two groups was compared.

RESULTS:The levels of TNF-α, IL-1, IL-6, IL-8 of control group were significantly lower than those of test group(P<0.05). After 1, 4 and 10wk of treatments, the observed indexes of two groups were significantly different(P<0.05). With the extension of treatment time, the indexes gradually returned to normal; at 1, 4 and 10wk after treatments, the levels of TNF-α, IL-1, IL-6, IL-8 of two groups were significantly different. The mentioned indexes were gradually reduced(P<0.05).

CONCLUSION:For patients with evaporative dry eye, TNF-α, IL-1, IL-6 and IL-8 increase specifically, which are closely correlated with the occur and progress of this disease, regarded as the important reference indexes for clinical diagnosis and efficacy monitoring.