方法：选取2014-01/12在上海交通大学附属同仁医院眼科接受sub-PRP的PPDR患者24例43眼作为观察组，同期接受PRP的PPDR患者37例66眼作为对照组。观察治疗前后视力和视网膜变化情况，并用OCT观察治疗前后黄斑厚度和容积变化情况。

结果：观察组治疗6mo后视力有效率和视网膜有效率分别为77%和81%，对照组视力有效率和视网膜有效率分别为76%和80%，两组无统计学差异(P>0.05)。观察组与对照组黄斑子区厚度及黄斑容积术后1mo达到最高，与术前相比均有统计学差异(P<0.05)，且观察组黄斑子区厚度及黄斑容积均明显低于对照组(P<0.05)。术后3mo观察组的黄斑子区厚度及黄斑容积已回落到术前(P>0.05)，对照组的黄斑子区厚度及黄斑容积仍高于术前，且高于观察组(P<0.05)。术后6mo两组的黄斑子区厚度及黄斑容积均低于术前(P<0.05)。

结论：sub-PRP对PPDR的疗效与PRP相当，并且对黄斑的影响较小。

METHODS: From January to December 2014, 61 patients with PPDR were divided into observation group(24 patients with 43 eyes who received sub-PRP)and control group(37 patients with 66 eyes who received PRP). Their clinical data and follow-up results were reviewed.

RESULTS: The efficiency rate of visual acuity and of retinopathy were 77% and 81% in observation group at 6mo after treatments. The two indicators in control group were 76% and 80% and the difference on the two indicators between the two groups were not statistically significant(P>0.05).The central macular thickness and volume of macula reached peak in both group at 1mo after photocoagulation and compared to those before treatments, the differences were statistically significant(P<0.05). The central macular thickness and volume of macula in observation group was significantly lower than those of control group(P<0.05). At 3mo after treatments, the central macular thickness and volume of macula in sub-panretinal photocoagulation group had returned to the level before treatments(P>0.05), while those of panretinal photocoagulation group were higher than those before treatments and those of observation group(P<0.05). At 6mo after photocoagulation, the central macular thickness and volume of macula were lower in both groups compared to those before treatments(P<0.05).

CONCLUSION: The effect of sub-PRP on PPDR is comparable to that of PRP, while the effect on the macula is smaller.