Abstract:AIM: To systemically evaluate the clinical efficacy and safety of intraocular implants for vitreous retinal surgery.
METHODS: We performed a comprehensive search for studies reporting vitreous surgery with intraocular implants randomized controlled and a retrospective controlled clinical trials from China Hownet(CNKI), Wanfang database, and VIP literature database. Studies obtained from those database were filtered according to the criteria, and data were retrieved from eligible studies for further analysis. Then we performed a meta-analysis to evaluate the efficacy and safety of intraocular implants using comprehensive Meta-analysis software version 2(Biostat, Englewood, NJ).
RESULTS: In total 36 studies were recruited for our Meta-analysis, including 5 092 cases. Meta analysis showed: 1)regarding the efficacy of repairing the retinal detachment, silicone oil was a better intraocular implants than C3F8(OR=1.76; 95% CI: 1.19-2.60, P=0.0047)and SF6(OR= 4.68; 95% CI: 1.48-14.81, P=0.0087); 2)regarding the risk of postoperative cataract, silicone oil showed significant higher risk than BBS(OR=3.24; 95% CI: 2.10-4.99, P=1.09 e-7), and C3F8(OR=3.03; 95% CI: 1.50-6.10, P=0.0019); 3)regarding the risk of postoperative intraocular pressure, silicone oil showed significant higher risk than BBS(OR=6.74; 95% CI: 3.38-13.41, P=5.67 e-08), and C3F8 also showed a higher risk than BBS(OR=4.79; 95% CI: 2.37-9.68, P=1.29 e-05). In addition, silicone oil showed significant lower risk as compared with heavy silicone oil(OR=0.16; 95% CI: 0.08-0.53, P=0.0026).
CONCLUSION: The intraocular implants for the treatment of retinal detachment in vitreous retinal surgery are mainly divided into two major categories, liquid and gas implants. The silicone oil, a major liquid implant, shows higher efficacy in terms of treating retinal detachment than the gas implants. However, the silicone oil is associated with a higher risk of postoperative cataract and intraocular pressure as compared with gas implants.
