方法：采用随机数字表法将我院急性视网膜坏死综合征患者30例40眼分为A、B两组，其中A组采用阿昔洛韦+醋酸泼尼松片的给药方案，B组采用丙氧鸟苷+醋酸泼尼松片+阿司匹林的给药方案，观察并比较两组患者治疗后的临床效果。

结果：经过治疗后，B组总有效率(90%)明显高于A组(70%)，两种给药方案均有效，差异无统计学意义(P>0.05)； 两组患者在治疗前视力情况差异无统计学意义(P>0.05)； 经不同给药方案治疗后，A组视力≥0.5者9眼，视力0.1～<0.5者3眼，视力0.02～<0.1者6眼，无感光者2眼，B组视力≥0.5者12眼，视力0.1～<0.5者4眼，视力0.02～<0.1者3眼，无感光者1眼， B组患者视力恢复情况优于A组，差异有统计学意义(P<0.05)； B组患者视网膜裂孔、疱疹、口腔溃疡、水痘、病毒性脑炎及中枢神经病变等并发症的发生率(10%)明显低于A组(35%)，差异有统计学意义(P<0.05)。

结论：阿昔洛韦+醋酸泼尼松片、丙氧鸟苷+醋酸泼尼松片+阿司匹林两种给药方案都具有较为肯定的治疗效果，但后者对患者视力的恢复及并发症发生率的降低具有更好的优势。

METHODS: Thirty patients(40 eyes)with acute retinal necrosis syndrome in our hospital were randomly divided into group A and B. Group A was treated with acyclovir with prednisone acetate tablets, and group B was given ganciclovir with prednisone acetate tablets and aspirin. Clinical effects in the two groups were observed and compared.

RESULTS: After treatment, the overall response rate in group B(90%)was obviously higher than that in group A(70%), both of two regimens were effective, without significant difference(P>0.05). There was no significant difference on the pre-treatment visual acuity between the two groups(P>0.05). After different treatments, the visual acuity in group B was ≥0.5 in 12 eyes, 0.1≤and<0.5 in 4 eyes, 0.02≤and<0.1 in 3 eyes, and no photosensitive in 1 eye. The visual acuity in group A was ≥0.5 in 9 eyes, 0.1≤and<0.5 in 3 eyes, 0.02≤and<0.1 in 6 eyes, and no photosensitive in 2 eyes. The recovery of visual acuity in group B was obviously better than that in A group(P<0.05). The incidence of complications such as retinal tear, herpes, mouth ulcers, chickenpox, viral encephalitis and central nervous system diseases in group B(10%)was significantly lower than that in A group(35%,P<0.05).

CONCLUSION: Two drug therapies(acyclovir with prednisone acetate tablets, ganciclovir with prednisone acetate tablets and aspirin)both have positive therapeutic effect, but the latter can better restore visual acuity and decrease the complications.