AIM: To observe the effect of intravenous methylprednisolone combined with peri-orbital injection of triamcinolone acetonide for diffuse-type orbital inflammatory pseudotumor.

METHODS: Diffuse-type orbital inflammatory pseudotumor in 15 cases(19 eyes)were treated. Intravenous implosive methylprednisolone therapy(0.5g/d)was used in the first 3d, and 0.5g once a week in the following 3wk, ended by 0.25g once a week in the last 6wk, which meant the total dose was 4.5g and the whole course lasted for 10wk. At the same time, peri-orbital injection of triamcinolone acetonide(40mg)was performed once in every 3wk, totally 2-4 times.

RESULTS: Eight eyes from 7 cases were completely cured, 11 eyes from 8 cases were partly cured. No recurrence and severe complications were observed in the treatment duration.

CONCLUSION: Intravenous methylprednisolone combined with peri-orbital injection of triamcinolone acetonide is effective, safe and feasible in treatment of diffuse type orbital pseudotumor with less complications.