AIM: To observe the clinical curative effect of the intravitreal injection of anti-VEGF antibody combined with the implantation of Ex-press glaucoma drainage device for neovascular glaucoma(NG).

METHODS:A retrospective analysis of 20 patients with NG, who got the intravitreal injection of anti-VEGF antibody combined with the implantation of Ex-press. The visual acuity, intraocular pressure(IOP), iris neovascularization fade and intraoperative and postoperative complications were observed at 1wk, 1, 3 and 6mo postoperatively.

RESULTS:The average IOPs of 20 patients were 47±5.6mmHg, 13.4±3.6mmHg, 15.3±4.2mmHg, 16.9±5.3mmHg and 18.7±6.9mmHg preoperatively and postoperatively 1wk, 1mo, 3mo and 6mo with statistical difference(P<0.05). The intraoperative and postoperative complications of the implantation of Ex-press mainly included early shallow anterior chamber, drainage tube obstruction, filtering bleb scarring. There were 8 eyes with filtering bleb scarring with normal IOP.

CONCLUSION: The intravitreal injection of anti-VEGF antibody combined with implantation of Ex-press is effective for NG, which can significantly reduce the IOP.