AIM: To analyze and discuss individual combination of femtosecond laser keratectomy excimer laser treatment of myopia clinical effect, thus providing the basis for clinical treatment.

METHODS: A total of 320 cases(509 eyes)with myopia were divided into the observation group and the control group according to the patient surgery program from Jan. 2010 to Jan. 2015 in the hospital. The observation group were treated with femtosecond laser combined with individual excimer laser keratectomy(ORK)treatment. The control group were treated with ORK mechanical knife treatment system valve.

RESULTS: In patients with low and moderate myopia, the average visual acuity of observation group and control group were 5.11±0.09 and 5.10±0.08 postoperative 6mo. The average visual acuity of observation group and control group were 5.09±0.05 and 5.08±0.05 postoperative 6mo in patients with high myopia. After treatment, the visual acuity was improved, and there was no significant difference between the two groups(P>0.05). After treatment, the observation group corneal aspherical coefficients Q were significantly lower than the control group(P<0.05). After treatment, the observation group corneal thickness was significantly thinner than the control group(P<0.05).

CONCLUSION: Femtosecond laser combined with individual excimer laser keratectomy for myopia has significant clinical effect and good surgical effectiveness. Also, it's better to maintain the aspheric shape of the cornea improved the visual quality.