方法：选取2010-01/2015-01在医院接受治疗的近视患者320例590眼， 根据患者手术方案分为观察组与对照组，观察组采用飞秒激光个体化准分子手术(optimized refractive keratectomy， ORK)进行治疗，对照组则为机械刀制瓣的ORK治疗。

结果：低中度近视患者中，观察组术后6mo平均视力为5.11±0.09，对照组为5.10±0.08。高度近视患者中，观察组术后6mo平均视力为5.09±0.05，对照组为5.08±0.05。两组患者术后视力均有所改善，且两组间差异无统计学意义(P>0.05)。术后6mo，观察组角膜非球面系数Q明显低于对照组，差异有统计学意义(P<0.05)。术后6mo观察组角膜厚度明显薄于对照组，差异有统计学意义(P<0.05)。

结论：飞秒激光个体化准分子手术治疗近视具有良好的手术有效性，且更好地保持了角膜的非球面形态，提高视觉质量。

METHODS: A total of 320 cases(509 eyes)with myopia were divided into the observation group and the control group according to the patient surgery program from Jan. 2010 to Jan. 2015 in the hospital. The observation group were treated with femtosecond laser combined with individual excimer laser keratectomy(ORK)treatment. The control group were treated with ORK mechanical knife treatment system valve.

RESULTS: In patients with low and moderate myopia, the average visual acuity of observation group and control group were 5.11±0.09 and 5.10±0.08 postoperative 6mo. The average visual acuity of observation group and control group were 5.09±0.05 and 5.08±0.05 postoperative 6mo in patients with high myopia. After treatment, the visual acuity was improved, and there was no significant difference between the two groups(P>0.05). After treatment, the observation group corneal aspherical coefficients Q were significantly lower than the control group(P<0.05). After treatment, the observation group corneal thickness was significantly thinner than the control group(P<0.05).

CONCLUSION: Femtosecond laser combined with individual excimer laser keratectomy for myopia has significant clinical effect and good surgical effectiveness. Also, it's better to maintain the aspheric shape of the cornea improved the visual quality.