Anti-vascular endothelial growth factor(anti-VEGF)drugs are widely used in the ophthalmology. The main indications are wet age-related macular degeneration(wAMD). By searching the related literature, we draw a lot of anti-VEGF drugs' rare application case reports and clinical research progress in Ophthalmic diseases except wAMD. There are still gaps between vitro and the clinical use of those researches. The prospect of the application of anti-VEGF drugs is hopeful and attractive. More researches is needed.