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[摘要]
目的：观察抗血管内皮生长因子(vascular endothelial growth factor，VEGF)药物玻璃体腔内注射及全视网膜光凝(panretinal photocoagulation，PRP)后联合滤过手术治疗新生血管性青光眼的疗效。
方法：对21例23眼患者中屈光介质透明者行抗VEGF药物玻璃体腔内注射及PRP后新生血管消退后行复合式小梁切除术，屈光介质混浊患者行白内障或玻璃体切除术及全视网膜光凝联合复合式小梁切除术，随访3mo，对治疗前后眼压情况进行比较。
结果：患者1例1眼视力提高显著，其余患者视力稳定或略有提高，所有患者虹膜新生血管均有不同程度消退。治疗前后眼压比较有统计学差异(P<0.01)，所有患者均未出现术中术后严重并发症。
结论：抗VEGF药物玻璃体腔内注射及PRP清除虹膜新生血管后联合滤过手术可以较快、较好地控制眼压，可有效治疗新生血管性青光眼。
[Key word]
[Abstract]
AIM: To observe the effects of intravitreous injection of anti-VEGF drug and PRP combined with filtering surgery for neovascular glaucoma.
METHODS:Twenty-three eyes of 21 patients with neovascular glaucoma were enrolled. The patients of ocular media transparency were treated with intravitreous injection of anti-VEGF drug and PRP combined with filtering surgery. The patients of ocular media opacity were treated with vitrectomy or cataract surgery in the meantime. All cases were followed for 3mo, IOP control were observed after treatment.
RESULTS:One patient visual acuity improved significantly, all remaining stable or slightly improve visual acuity. All case showed regress at different degree of the iris neovessels. There was significant difference between before and after treatment(P=0.00).
CONCLUSION:The intravitreous injection of anti-VEGF drug and PRP combined with filtering surgery for neovascular glaucoma provide more rapid control of IOP. It is a better choice of neovascular glaucoma.
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