目的：通过对睑板腺功能障碍(meibomian gland dysfunction，MGD)患者行飞秒激光LASIK后弥漫性层间角膜炎(diffuse lamellar keratitis，DLK)发生情况的临床观察，分析睑板腺功能障碍与DLK发生的相关性。

方法：收集2015-01/10就诊于我院近视治疗中心符合飞秒激光LASIK手术适应证，并进行手术者200例396眼，分成两组观察，A组为试验组(MGD组)，有睑板腺功能障碍的患者100例197眼； B组为对照组(无MGD组)，无睑板腺功能障碍的患者100例199眼。A组与B组之间年龄与性别差异无统计学意义。术前观察睑板腺开口阻塞情况、睑板腺分泌质和量、睑缘异常情况。观察术后1、3d，1wk DLK发生情况及严重程度。

结果：MGD组100例197眼中发生DLK为15例18眼，发生率为9.1%； 无MGD组100例199眼中发生DLK为3例3眼，发生率为1.5%； MGD组DLK的发生比率明显高于无MGD组。两组间DLK发生率存在明显的统计学差异(P<0.05)。

结论：MGD可能是飞秒激光LASIK术后DLK发生的一种潜在危险因素。

AIM: To analyze the correlation between Meibomian gland dysfunction and the incidence of diffuse lamellar keratitis(DLK)by giving Meibomian gland dysfunction patients femtosecond laser assisted laser in situ keratomileusis(LASIK)operations and observing the occurrence of DLK clinically after operations.

METHODS: Selected 200 patients(396 eyes)who received femtosecond laser LASIK operations in Myopia Treatment Center from January 2015 to October 2015 and divided them into two groups for observation. Group A was the experimental group(MGD group)with 100 meibomian gland dysfunction patients(197 eyes). Group B was the control group(non- MGD group)with 100 patients(199 eyes)without meibomian gland dysfunction. There were no significant differences in age and gender in the two groups. Meibomian gland orifice obstruction, quality and quantity of meibomian gland secretions and palpebral margin anomalies were observed before operations and the occurrence and severity of DLK were observed on 1, 3d and 1wk after operations by using slit lamp-microscopy.

RESULTS: In MGD group, among the 100 patients(197 eyes), 15 patients(18 eyes)had DLK. The occurrence rate was 9.1%. In the 100 patients(199 eyes), 3 patients had DLK. The occurrence rate was 1.5%. The occurrence rate of DLK in MGD group was significantly higher than that in non-MGD group. There were statistically significant difference(P<0.05)in the incidence of DLK between the MGD group and non- MGD group.

CONCLUSION: The result of analysis indicated that MGD may be a potential risk factor for the occurrence of DLK after the femtosecond laser LASIK operation.