Uveal melanoma(UM)is the most common primary intraocular malignant tumor of adult. The traditional treatment is enucleation, but it cannot completely avoid metastasis, and on the contrary, it stimulates to distant metastasis of tumor cells to some extent. According to the statistic of latest 30a, survival rates of UM patients with metastasis is still very low. Recently, many researches devoted to targeted therapy, immune therapy and radiotherapy, which have achieved gratifying results. We summarized these relative researches in this paper.