AIM: To estimate the efficacy and safety of intravitreal injections of 0.5mg conbercept combined with 532-laser retinal photocoagulation for retinal vein occlusion(RVO).

METHODS: Totally 122 cases(122 eyes)checked in hospital for RVO were randomly divided into two groups by using the random number list during May 2015 to March 2016. The research group with 58 cases(58 eyes)comprised of 24 cases(24 eyes)diagnosed as central retinal vein occlusion and 34 cases(34 eyes)diagnosed as branch retinal vein occlusion. The control group with 64 cases(64 eyes)comprised of 26 cases(26 eyes)diagnosed as central retinal vein occlusion and 38 cases(38 eyes)diagnosed as branch retinal vein occlusion. All the cases were treated with intravitreal conbercept injections while the research group combined with treatment of received 532-laser retinal photocoagulation pre-injection. Optical coherence tomography(OCT)was adapted pre and 1,3 and 6mo after intravitreal injection. The best corrected visual acuity(BCVA), thickness of macular central concave and retinal pigment epithelium uplift area were compared between the two groups.

RESULTS: BCVA of all cases were increased 1, 3 and 6mo after treatment, and the difference had statistical significance(P<0.05). The research group had a better improvement of BCVA than control group, and there were significant differences between the two groups 3, 6mo after treatment but 1mo. Thickness of macular central concave and retinal pigment epithelium uplift area of two groups were decreased 1, 3 and 6mo after treatment, the difference had statistical significance(P<0.05). The research group had a bigger decrease value than the control group as for thickness of macular central concave and retinal pigment epithelium uplift area, there were significant differences between two groups 3, 6mo after treatment but 1mo. No adverse events occurred during the treatment.

CONCLUSION: Intraviteal conbercept injection can increase the visual acuity and decrease both the thickness of macular central concave and retinal pigment epithelium uplift area of patients with retinal vein occlusion. Combined with 532-laser retinal photocoagulation will achieve better outcome than intravitreal injection only.