方法：选取2014-01/2015-12在本院进行治疗的120例204眼Ⅲ～Ⅳ期DR患者进行研究，均采用全视网膜激光光凝术治疗，采用随机数字表法分为研究组(66例116眼，加用羟苯磺酸钙治疗)和对照组(54例88眼，未用羟苯磺酸钙治疗)，对比两组患者治疗的临床效果。

结果：术后6mo，研究组的最佳矫正视力(best corrected visual acuity，BCVA)检测值高于对照组，差异具有统计学意义(P<0.05)； 术后3、6mo，研究组的视网膜新生血管荧光素渗漏面积均低于对照组，差异具有统计学意义(P<0.05)； 术后3、6mo，研究组的黄斑中心凹厚度(central macular thickness，CMT)测定值均低于对照组，差异具有统计学意义(P<0.05)； 研究组有4眼出现术后并发症(3.4%)，与对照组(5眼，5.7%)比较，差异无统计学意义(P>0.05)。

结论：Ⅲ～Ⅳ期DR患者采用全视网膜激光光凝联合羟苯磺酸钙治疗，较单纯全视网膜激光光凝治疗能进一步改善临床效果，减轻视网膜新生血管荧光素渗漏面积及CMT。

METHODS: Selected 120 cases(204 eyes)of DR patients who were treated in our hospital from January 2014 to December 2015 were randomly divided into study group(116 eyes in 66 patients)with calcium hydroxide, control group(88 eyes in 54 patients). Two groups were treated with panretinal laser photocoagulation, and the clinical effect of the two groups were compared.

RESULTS: At 6mo after surgery, BCVA of study group was higher than that of control group, the difference was statistically significant(P<0.05); at 3 and 6mo after operation, fluorescein leakage area of the study group were lower than that of control group, the difference was statistically significant(P< 0.05); at 3 and 6mo after surgery, central macular thickness(CMT)of the study group was lower than that of control group, the difference was statistically significant(P<0.05); the study group had complications after surgery in 4 eyes(3.4%)and 5 eyes(5.7%)in control group, the difference was not statistically significant(P>0.05).

CONCLUSION: Compared with simple laser photocoagulation, panretinal laser photocoagulation combined with calcium hydroxide for III - IV stage DR reduce fluorescein leakage area and CMT.