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[摘要]
目的:探讨不同药物治疗白内障术后干眼症的疗效。
方法:收集我院2014-06/2016-06 间我院接诊的白内障术后干眼症患者共60例120眼,根据就诊顺序分为单纯玻璃酸钠滴眼液组20例40眼,玻璃酸钠滴眼液联合普拉洛芬滴眼液组20例40眼; 玻璃酸钠滴眼液联合普拉洛芬滴眼液及杞菊地黄丸组20例40眼。所有患者均治疗1mo,观察记录治疗前,治疗后1、2wk,1、3mo的泪膜破裂时间(break up time, BUT),泪液分泌试验(Shimmer Ⅰ test, S Ⅰ t),角膜荧光素钠染色(fluorescein corneal staining, FL)。
结果:三组治疗后1mo有效率比较,差异具有统计学意义(P<0. 05)。BUT:三组治疗前比较差异无统计学意义(P>0. 05)。各组治疗后1,3mo与治疗前比较差异有统计学意义(P<0. 05)。三组间治疗后1、2wk,1mo比较差异有统计学意义(P<0. 05),治疗后3mo三组比较差异虽无统计学意义(P>0. 05),但玻璃酸钠滴眼液联合普拉洛芬滴眼液及杞菊地黄丸组(12.14±1.97s)明显优于单纯玻璃酸钠滴眼液组(10.54±1.88s)和玻璃酸钠滴眼液联合普拉洛芬滴眼液组(12.05±1.63s)。SⅠt:三组治疗前比较差异无统计学意义(P>0.05)。各组治疗后1,3mo与治疗前比较差异有统计学意义(P<0.05)。三组治疗后1、2wk,1mo比较差异有统计学意义(P<0.05),治疗后3mo三组比较差异虽无统计学意义(P>0.05),但玻璃酸钠滴眼液联合普拉洛芬滴眼液及杞菊地黄丸组(14.24±1.89mm/5min)明显优于单纯玻璃酸钠滴眼液组(12.22±2.54mm/5min)和玻璃酸钠滴眼液联合普拉洛芬滴眼液组(12.27±2.31mm/5min)。FL :三组治疗前比较差异无统计学意义(P>0.05)。各组治疗后1、3mo与治疗前比较差异有统计学意义(P<0.05)。三组治疗后1、2wk,1mo比较差异有统计学意义(P<0.05)。治疗后3mo三组比较差异无统计学意义(P>0.05)。
结论:玻璃酸钠滴眼液联合普拉洛芬滴眼液及杞菊地黄丸治疗白内障术后干眼效果优于玻璃酸钠滴眼液联合普拉洛芬滴眼液组及单纯应用玻璃酸钠滴眼液,并且能够更好改善视觉功能,提高泪膜稳定性,得到更好地治疗效果。
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[Abstract]
AIM: To explore the therapy efficacy of different drugs for dry eyes after cataract surgery.
METHODS: Collected from June 2014 to June 2016 in patients with dry eyes in our departments of cataract surgery, a total of 60 cases with 120 eyes, according to the doctor order divided into pure sodium hyaluronate eye drops group 20 cases(40 eyes, sodium hyaluronate eye drops combined pranoprofen eye drops group 20 cases(40 eyes), sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group of 20 cases(40 eyes). All patients were treated for 1mo. Observation of break up time(BUT), Shimmer Ⅰ test(SIt)and fluorescein corneal staining(FI)were recorded before the treatment and 1, 2wk, 1, 3mo after treatment.
RESULTS: Difference of efficient rates of three groups 1mo after treatment were statistically significant(P<0.05). BUT: there was no statistically significant difference among three groups before treatment(P>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(P<0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(P<0.05); at 3mo after treatment the difference among the three groups was not statistically significant(P>0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(12.14±1.97s)was superior to pure sodium hyaluronate eye drops group(10.54±1.88s)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.05±1.63s).SIt: there was no statistically significant difference among three groups before treatment(P>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(P<0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(P<0.05); but sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill group(14.24±1.89mm/5min)was superior to pure sodium hyaluronate eye drops group(12.22±2.54mm/5min)and sodium hyaluronate eye drops combined pranoprofen eye drops group(12.27±2.31mm/5 min).FL: there was no statistically significant difference among three groups before treatment(P>0.05); at 1, 3mo after treatment compared with before treatment, the differences of the three groups were statistically significant(P<0.05); among the three groups 1, 2wk and 1mo after treatment, the differences were statistically significant(P<0.05); at 3mo after treatment the difference among the three groups was not statistically significant(P>0.05).
CONCLUSION:Sodium hyaluronate eye drops combined pranoprofen eye drops and Qiju Dihuang pill in the treatment of dry eye after cataract surgery is better than that of sodium hyaluronate eye drops combined pranoprofen eye drops group and simple application of sodium hyaluronate eye drops, which can better improve the visual function, improve tear film stability, get better treatment effect.
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