AIM:To investigate the curative effect of surgical resection combined with 100% concentration of autologous serum eye drops in the treatment of pterygium.

METHODS: Totally 120 cases of 120 eyes with pterygium from March 2015 to March 2016 in Zhongxiang People's Hospital were randomly divided into the control group and the experimental group. All patients were treated with tobramycin and dexamethasone ophthalmic ointment bandaged eyes postoperatively, and the next day tobramycin and dexamethasone eye drop were used, 2 drops, 6 times per day. The control group was treated with polyvinyl alcohol eye drops, 2 drops, 6 times per day, but the test group were treated with autologous blood concentration of 100% concentration of autologous serum eye drops, 2 drops, 6 times per day. The two groups were treated for 3wk. The curative effect was evaluated after operation of 3mo.

RESULTS: The preoperative general condition, ocular symptoms and signs score and Schirmer test of the two groups was no significant different(P>0.05). But there were significant differences of the two groups on ocular symptoms and signs score, corneal epithelium and/or matrix defect area and repair time, Schirmer test after the operation(P<0.05). In control group, the recurrence rate was 6.7%. And the experimental group were 3.3%. There was significant difference between the two groups(P<0.05).

CONCLUSION:The application of 100% concentration of autologous serum eyedrops after pterygium resection combined with autologous limbal stem cell transplantation of conjunctival flap was better for wound healing and ocular surface reconstruction postoperatively, and it achieved good curative effect.