AIM: To investigate the clinical effect and complication of orthokeratology for myopia.

METHODS: From August 2014 to October 2015, 204 adolescents(408 eyes)with myopia in our hospital, were treated with orthokeratology, and followed up at 1, 3, 6 and 12mo for visual acuity, corneal curvature, axial length and so on.

RESULTS: The visual acuity was significantly improved than before wearing(P<0.05). At 1, 3, 6 and 12mo after wearing, the visual acuity were 0.52±0.12, 0.64±0.20, 0.95±0.15 and 0.97±0.12; after wearing the diopter significantly decreased than before wearing(P<0.05); at 1, 3, 6 and 12mo after wearing diopter were 1.82±0.40D, 0.96±0.20D, 0.40±0.09D and 0.25±0.06D. There was no significant difference in the corneal curvature, axial length, corneal endothelial cell density and central thickness between before and after wearing(P>0.05). After wearing the anterior corneal surface curvature radius significantly increased than before wearing(P<0.05). At 1, 3, 6 and 12mo after wearing, anterior corneal surface curvature radius were 7.90±0.21 mm, 8.20±0.22mm, 8.24±0.23mm and 8.30±0.26mm. There was no significant difference on the posterior corneal surface curvature radius and anterior chamber depth between before and after wearing(P>0.05).

CONCLUSION: Orthokeratology correcting myopia, is safe and effective with no obvious effect on corneal endothelial cells and anterior chamber depth. There is a certain scope of application for the correction of myopia.