AIM: To analyze the effect of myopic adolescents wearing orthokeratology lens on the corneal surface curvature radius and anterior chamber depth.

METHODS: Totally 120 cases of adolescent myopia were selected, among them 58 cases with 116 eyes were divided into 11-14 years old group and 62 cases with 124 eyes were 15-18 years old group according to the age. They were treated with long-term orthokeratology lens treatment, and two groups of patients were observed before wearing lens(T0), wearing for 6mo(T1), 12mo(T2)for uncorrected visual acuity, the average refractive degree improvement, the central corneal thickness, corneal curvature changes and the incidence of complications.

RESULTS: The uncorrected visual acuity of the two groups at 12mo after wearing were better than that at 6mo which was better than that before wearing; the diopter had the same trend. The uncorrected visual acuity and the diopter of the 11-14 years old group at 6 and 12mo was better than those of 15-18 years old group with significant difference(P<0.05). The central corneal thickness of the two groups at 12mo after wearing were less than that at 6mo which was less than that before wearing. There was no significant difference of the central corneal thickness between the two groups at 6 and 12mo after wearing(P>0.05). The corneal anterior surface curvature of the two groups at 12mo after wearing were more than that at 6mo which was more than that before wearing. The axial length of the 11-14 years old group was longer than that of the 15-18 years old group with significant difference(P<0.05). There was no significant difference on the corneal posterior surface curvature of the two groups before and after wearing(P>0.05). There was no significant difference on the anterior chamber depth between the two groups at different time or between before and after wearing(P>0.05).

CONCLUSION: Long-term wearing orthokeratology lenses have a significant effect for control ling juvenile myopia, and can improve the corneal anterior surface curvature, especially in the lower age group, and has no significant effect on the anterior chamber depth.