AIM: To investigate the effect of mydriasis optometry combined with amblyopia treatment on refraction and amblyopia changes in children with mixed astigmatism and amblyopia.

METHODS: Totally 163 children(289 eyes)of mixed astigmatism and amblyopia from January 2010 to May 2011 were treated. All of the patients received mydriatic optometry and spectaculars with amblyopia therapy and were followed up for 5a to observe amblyopia efficacy and refractive status changes.

RESULTS: With 5a, main diameter diopter at distant vision decreased year by year, average decline in the first year was 0.55DS, 0.56DS in the second year, 0.72DS in the third year, 0.95DS in the fourth year, 1.89DS in the fifth year. The spherical equivalent changed from 1.12DS at distant to 0.78DS at near. The corrected visual acuity of all the patients at first visit was 0.2-0.8 with varying degrees amblyopia. After a 5-year treatment, it was effective in 268 eyes(92.7%), in which 165 eyes(57.1%)improved, 103 eyes(35.6%)cured, the results was better as the period of spectaculars wearing was longer. There was 36 eyes(37.5%)improved and 60 eyes(62.5%)cured in 1.50-2.50DC group; 118 eyes(74.2%)improved, 41 eyes(25.8%)cured in 2.50-3.50DC group; 11 eyes(32.3%)improved, 2 eyes(5.9%)cured, 21 eyes(61.8%)useless in >3.50DC Group. The differences of efficacy among the groups were significant(all P<0.05).

CONCLUSION: Appropriate spectaculars is the basic for amblyopia treatment. It is effective for most children with mixed astigmatism and amblyopia to take mydriasis optometry and amblyopia treatment.