方法：前瞻性横断面研究。研究包含马来西亚医科大学的40例OSA患者和31例正常人。随机选取眼部未发生病变并确诊OSA的患者参与研究。通过记录呼吸暂停低通气指数(AHI)以用于对OSA的严重程度分层。由马来西亚医科大学眼科电生理实验室内训练有素的技术人员对每位患者进行电生理检查(PVEP和PERG)。所得结果记录为中位数。 使用IBM Statistics Version 21.0完成数据分析。

结果：在OSA患者中，与正常人相比，我们观察到PERG的P50振幅(P<0.001)和PVEP的P100振幅(P<0.001)显著降低。OSA患者PVEP的P100(P=0.003)和N75的峰值时间(P=0.004)均显著升高。然而在OSA患者和正常人之间的PERG的峰值时间检测无显著差异。在不同疾病严重程度的OSA患者中PVEP或PERG也无显着差异。

结论：OSA患者PVEP幅度和峰值时间及PERG幅度存在显著异常。这可能反映了OSA中的亚临床视神经功能障碍。 需要进一步的研究来确定OSA的严重程度与视神经功能障碍程度之间的关系。

METHODS: This was a prospective cross-sectional study involving 40 OSA patients and 31 control subjects in Hospital Universiti Sains Malaysia. Patients with a confirmed diagnosis of OSA who had no ocular pathology were randomly selected to participate in the study. The apnoea-hypopnoea index(AHI)was obtained from their records and used for stratification of OSA severity. Electrophysiological tests(PVEP and PERG)were performed on each patient by a trained technician in the electrophysiology laboratory of the Department of Ophthalmology, USM. The results obtained were recorded as median values. Data analysis was done using IBM Statistics Version 21.0.

RESULTS: Among OSA patients, we observed a significant reduction of the PERG amplitude P50(P<0.001)and the PVEP amplitude P100(P<0.001)compared to the control group. OSA patients also had a significant increase in PVEP time to peak P100(P=0.003)and time to peak N75(P=0.004). However, no significant differences were detected in PERG time to peak between OSA patients and controls. There were likewise no significant differences in PVEP or PERG between OSA patients with different disease severity.

CONCLUSION: OSA patients have significant abnormalities in PVEP amplitude and time to peak, as well as PERG amplitude. This may reflect subclinical optic nerve dysfunction in OSA. Further research is needed to determine the association between the severity of OSA and the degree of optic nerve dysfunction.