方法：回顾性病例系列研究。对2016-03/12于煤炭总医院眼科门诊临床诊断为干眼症的糖尿病患者进行糖尿病病史调查及干眼相关检查。干眼相关检查包括泪膜破裂时间(break-up time，BUT)和泪液分泌试验(schirmer Ⅰ test， SⅠt)检查。以患者的年龄分为<60岁和≥60岁组； 依据糖尿病病程分为<5a组、5～9a组、≥10a组； 根据血糖控制情况分为血糖控制组和血糖未控制组。将检测结果与患者性别、年龄、糖尿病病程、血糖控制状况进行统计学分析。

结果：共收集临床诊断为干眼的糖尿病患者共178例356眼，患者年龄32～85(平均58.41±13.06)岁。男110例220眼(61.8%)，女68例136眼(38.2%)。患者的BUT平均值为4.52±2.31s，SⅠt平均值为4.25±1.99mm/5min。两种检测方法中，女性均比男性的检测结果平均值稍高，其差异均无统计学意义(P>0.05)； ≥60岁组患者的检测结果平均值都低于<60岁组患者，其差异有统计学意义(t=4.153、4.021， P<0.01)； 病程<5a组、5～9a组及≥10a平均值均低于正常，≥10a组最低，5～9a组次之，<5a组最高，差异均有统计学意义(F=68.884、60.204， P<0.01)； 血糖控制组的BUT及SⅠt平均值明显高于血糖未控制组，其差异有统计学意义(t=-6.615、-5.918， P<0.01)。

结论：糖尿病患者干眼表现为泪膜不稳定性和泪液分泌减少两种类型，与糖尿病患者年龄、病程和血糖控制情况有一定的相关性。

METHODS: Retrospective case series study. Dry eye cases with type 2 diabetic were analyzed from March to December in 2016. And the clinical features of patients were summarized. Dry eye examination including tear break-up time(BUT)and Schirmer test(schirmer Ⅰ test, SⅠt). Patients were divided into <60 years and≥60 years group by the age. And patients were divided into <5 group, 5-9 years group, ≥10 years according to the duration of diabetes. According to the condition of blood glucose, patients were divided into glucose controlled group and the group blood glucose uncontrolled. The results were statistically analyzed with gender, age, duration of diabetes and blood glucose level.

RESULTS: There were 178 cases collected. All cases were diagnosed as dry eye both eyes. The patient's age ranged from 32 to 85 years, with an average 58.41±13.06 years. There were 110(61.8%)male cases, and 68(38.2%)female cases. In all cases, the mean value of BUT was 4.52±2.31s, and the mean value of SⅠt was 4.25±1.99mm/5min. The value of women were more than men, but the differences were not significant statistically. Patients of ≥60 group were less than the age group of <60 patients, and the difference was significant statistically(t=4.153, 4.021; P<0.01). In different course, all groups were lower than the normal. The value of≥10 years group was the least, <5 years group was the highest, and 5-9 years group was middle one. The differences were statistically significant(F=68.884, 60.204; P<0.01). The value of blood glucose controlled group was significantly higher than the group blood glucose uncontrolled, and the difference was statistically significant(t=-6.615, -5.918; P<0.01).

CONCLUSION:There were two types dry eye in 2 diabetic patients: the instability of tear-film and the reduction of tear secretion. The clinic features of dry eye were related to age, the course of the disease, and the level of blood glucose.