AIM:To evaluate the percentage of cutting fluctuations of central corneal thickness(CCT)intraoperative used low concentration(0.02%)mitomycin C(MMC)after laser-assisted subepithelial keratomileusis(LASEK).

METHODS: In this prospective study, low and medium myopia group(spherical equivalent≤6.0DS)has 138 patients(276 eyes). Low concentration MMC used topically in 69 patients(138 eyes)randomized after excimer laser ablation; the another traditional LASEK as control. High myopia group(6.0DSt test and their repeatability was assessed using the coefficient of variation(CV).

RESULTS: At 3mo after operation, the difference of central corneal thickness and cutting value between different treatment groups was statistically significant(P<0.05). The percentage of cutting fluctuations, which used to avoid the interference of the individual central corneal thickness between the applying low concentration MMC group and control group: the minimum value achieved at 1mo after LASEK, the maximum value achieved at 3mo after LASEK, the difference was statistically significant compared with the other 5 periods after LASEK within group(P<0.05); the difference in each period after LASEK was statistically significant(P<0.05)between groups with different treatmemt(P<0.05).

CONCLUSION: The study on percentage of cutting fluctuations of central corneal thickness, further confirmed low concentrations MMC in reducing postoperative corneal stromal proliferation reaction, inhibition of haze production.