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[摘要]
目的：探讨F-10共焦激光扫描检眼镜(cSLO)retro-mode成像在年龄相关性黄斑变性(AMD)玻璃膜疣检查中的应用价值。
方法：回顾性病例研究。选取 2015-10/2016-12于我院眼科门诊确诊的AMD患者67例67眼和对侧67眼的临床资料纳入研究。所有患者均行眼底彩色照相、光学相干断层扫描(optical coherence tomography，OCT)和F-10cSLOretro-mode成像检查。对比观察单侧AMD患者患眼玻璃膜疣的眼底彩色照相、OCT及retro-mode成像图像特征，并计算分析retro-mode成像与眼底彩色照相及OCT对单侧AMD患者对侧眼玻璃膜疣的检出率。
结果：F-10cSLOretro-mode成像能够清晰显示单侧AMD患者患眼一些在眼底彩色照相和OCT检查中并未出现的玻璃膜疣病灶。在67例单侧AMD患者对侧眼，retro-mode成像发现玻璃膜疣56眼(84%)，眼底彩色照相发现玻璃膜疣36眼(54%)，OCT发现玻璃膜疣48眼(72%)，差异有统计学意义(χ2=14.31，P<0.05)。两两分别比较，retro-mode成像对玻璃膜疣的检出率显著高于眼底彩色照相，差异有统计学意义(χ2=13.87，P'<0.0125)； 而retro-mode成像与OCT比较对玻璃膜疣的检出率差异无统计学意义(χ2=2.75，P'>0.0125)。
结论：F-10cSLOretro-mode成像作为一种非侵入性的检查方法，能够有效地检测AMD玻璃膜疣。
[Key word]
[Abstract]
AIM: To discuss the application value of retro-mode imaging by F-10 confocal scanning laser ophthalmoscope(cSLO)for detecting drusen in patients with age-related macular degeneration(AMD).
METHODS: This was a retrospective case study. During the period of October 2015 to December 2016, 67 patients with unilateral AMD(67 affected eyes and 67 fellow eyes)were included in this study. All patients underwent color fundus photography, optical coherence tomography(OCT)and retro-mode imaging by F-10 cSLO. The features of drusen by color fundus photography, OCT and retro-mode imaging were comparatively observed in the affected eyes of patients with unilateral AMD. Positive numbers of drusen in the fellow eyes of patients with unilateral AMD detected by color fundus photography, OCT and retro-mode imaging were calculated and compared.
RESULTS: Retro-mode imaging by F-10 cSLO gave easier to identify images of drusen than color fundus photography and OCT in the affected eyes of patients with unilateral AMD. In the fellow eyes of 67 patients with unilateral AMD, retro-mode imaging showed drusen in 56 cases(84%), color funds photography showed drusen in 36 cases(54%), OCT showed drusen in 48 cases(72%), the difference was statistically significant(χ2=14.31, P<0.05).The positive numbers of drusen detected by retro-mode imaging were significantly higher than color fundus photography, the difference was statistically significant(χ2=13.87, P'<0.0125). There was no statistically significant difference in the positive numbers of drusen detected by retro-mode imaging and OCT(χ2=2.75, P'>0.0125).
CONCLUSION: Retro-mode imaging by F-10 cSLO provides a non-invasive technique and should be useful for detecting and monitoring drusen in AMD.
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