目的：探讨叶黄素干预对早期年龄相关性黄斑变性(age-related macular degeneration，AMD)患者视功能的影响。

方法：采用随机双盲空白对照的方法，将200例早期AMD患者随机分为叶黄素干预组(20mg/d)和安慰剂对照组。分别于基线、12、24、36、48wk进行问卷调查、血清叶黄素密度及视功能检查。

结果：叶黄素干预组12、24、36、48wk的血清叶黄素密度比安慰剂对照组高(P<0.05)，血清叶黄素密度较基线升高(P<0.05)。叶黄素干预组24、48wk的对比敏感度(contrast sensitivity，CS)的低(3c/d)、中(6c/d)频段，黄斑色素光学密度(macular pigment optical density，MPOD)，最佳矫正视力(best-spectacle corrected visual acuity，BCVA)高于安慰剂对照组(P<0.05)； CS的低、中频段高于基线(P<0.05)，MPOD、BCVA与基线比较差异无统计学意义(P>0.05)。

结论：叶黄素干预可改善早期AMD患者的视功能。

METHODS: Totally 200 early AMD patients were divided into lutein intervention group(20mg/d)and placebo group by a randomized, double-blind, placebo-controlled trail. Questionnaire investigation, serum lutein concentration and visual function were conducted at baseline, 12, 24, 36 and 48wk respectively.

RESULTS: The serum lutein concentration in lutein intervention group was higher than the baseline(P<0.05)and those of placebo group at 12, 24, 36 and 48wk after intervention(P<0.05). The spatial frequencies of contrast sensitivity(CS)at low(3 cycles/degree)and medium(6 cycles/degree)in lutein intervention group, macular pigment optical density(MPOD)and best-spectacle corrected visual acuity(BCVA)were higher than those of placebo group(P<0.05). Contrasted to baseline, the low and medium spatial frequencies of CS in lutein intervention group were higher(P<0.05), while, there were no statistical significance in MPOD and BCVA between before and after treatment(P>0.05).

CONCLUSION: Lutein intervention can improve the visual function of patients with early AMD.