AIM: To systemically evaluate the clinical efficacy and safety of domestic deproteinized calf blood extract eye gel for corneal epithelial repair after laser refractive surgery.

METHODS:We performed a comprehensive search via Pubmed, Embase, Cochrane Library, VIP Chinese Science and Technology Journal Database, CNKI and Wan Fang Chinese periodical Database for the randomized controlled trials(RCTs)at home and abroad about effects of the domestic deproteinized calf blood extract eye gel for corneal epithelial repair after laser corneal refractive surgery with retrieval time from January 2007 to December 2016. According to the inclusion and exclusion criteria, 2 medical researchers independently screened documents, extracted data and evaluated the quality. Review Manager 5.3 software was used for Meta analysis.

RESULTS: Seven RCTs involving 1 042 eyes, including 523 eyes in the treatment group and 519 eyes in the control group, were selected for this Meta-analysis. The results showed that the clinical efficacy in the treatment group was better than that in the control group(OR=1.81, 95%CI: 1.39～2.35; P<0.001). And the corneal injury symptom score in the treatment group was superior to that in the control group(WMD=-0.33, 95%CI: -0.45 to -0.21; P<0.001). And the corneal healing time in the treatment group was shorter than that in the control group(WMD=-1.26, 95%CI: -1.56 to -0.97; P<0.001).

CONCLUSION: The domestic deproteinized calf blood extract eye gel can relieve the patients' symptoms after laser refractive surgery, improve the corneal epithelial recovery and the efficiency of treatment. Due to the limited quality and quantity of the studies these conclusions should be further validated by more well-designed randomized double blind controlled trials.