AIM: To investigate the value of ANA, ANCA, HLA-B27, anti-dsDNA in the diagnosis of immune-related uveitis.

METHODS: Totally 70 patients with immune-related uveitis were selected and the clinical data were collected. The levels of ANA, ANCA, anti-dsDNA in serum and HLA-B27 in peripheral blood lymphocytes were measured.

RESULTS: Male patients were younger than femle patients(t=2.845, P<0.05); there were 42 cases, 12 cases, 6 cases, 5 cases, 4 cases, 1 case, repectively in spondyloarthritis, primary systemic vasculitis, systemic lupus erythematosus, primary Sjogren's syndrome, rheumatoid arthritis and juvenile idiopathic arthritis among the 70 patients with immune-related uveitis. The proportion of spondylitis and systemic lupus erythematosus between men and women had significant difference(P=0.019, 0.008). The ANA positive rate was 16%(11/70), the positive rate of ANCA was 10%(7/70), the positive rate of HLA-B27 was 59%(41/70), the positive rate of anti-dsDNA was 6%(4/70). Among the cases, in male ANA, ANCA, anti-dsDNA positive rate was lower than in women(P<0.05). The positive rate of HLA-B27 in male was higher than that in female, the difference was significant(χ²=4.427, P<0.05). The main site of the disease in 70 cases of immune-related uveitis were the anterior uvea(49%)and the entire uvea(46%). ANA was mainly expressed in systemic lupus erythematosus(83%)and primary Sjogren's syndrome(60%); ANCA was expressed in immune-related uveitis(except for spondyloarthritis and juvenile idiopathic arthritis); HLA-B27 was predominantly expressed in spondylarthritis(93%); anti-dsDNA was mainly expressed in systemic lupus erythematosus(67%)and rheumatoid arthritis(25%).

CONCLUSION: The positive rates of ANA, ANCA, HLA-B27 and anti-dsDNA are different in different immunological-related uveitis, which has a certain diagnostic effect on the classification of immune-related uveitis.