AIM:To explore the correlation between choroidal thickness and macular hole, and to provide a theoretical basis for diagnosis and treatment of macular hole.

METHODS: This study included 40 cases of monocular idiopathic macular hole patients who were treated in ophthalmology of our hospital from June 2015 to June 2016 and 40 cases of healthy people. Sicked eyes of idiopathic macular hole patients(40 eyes)were set as the Group A, uninjured side eyes(40 eyes)were set as the Group B, eyes of 40 cases of healthy people(40 normal eyes)were set as the Group C. Choroidal thickness of macular fovea, macular fovea 1mm, 3mm at 9 points, 4 directions in the upper, lower, nasal and temporal regions were measured through coherent optical tomography of enhanced deep imaging(enhanced depth image optical coherence tomography, EDI-OCT). They were recorded as SFCT, SCT_1mm, SCT_3mm, ICT_1mm, ICT_3mm, NCT_1mm, NCT_3mm, TCT_1mm, TCT_3mm, and correlation analysis between SFCT and age was analyzed.

RESULTS: Average SFCT of Group A, B had no significant difference, data of the Group C was significantly higher than those of the Group A, B, there was statistical significance(P<0.05). SCT_1mm, SCT_3mm, ICT_1mm, ICT_3mm, NCT_1mm, NCT_3mm, TCT_1mm, TCT_3mm of the Group A, B had no significant difference(P>0.05), and choroidal thickness at each point of the Group C was significantly higher than that of Group A and B, there was statistical significance(P<0.05). Correlation analysis of age found that there was no significant correlation between SFCT and age of the Group A, B(r=-0.065, P=0.148; r=-0.057, P=0.658), SFCT of the Group C was negatively correlated with age(r=-0.343, P=0.041).

CONCLUSION: The pathogenesis of idiopathic macular hole may be related to the sharp decrease of choroidal thickness, choroidal thickness of uninjured side eyes reduces more sharply than normal population and choroidal vascular metabolism reduces may be pathogenic.