AIM: To assess the efficacy and safety of orthokeratology for reducing the progression of myopia in Asia children.

METHODS: Seven databases, including the Cochrane Library, Medline, EMbase, CBM, CNKI, VIP, and WanFang Data, were searched. The published languages were limited to English and Chinese. The risk bias tool provided by Cochrance cooperation and methodological index for non-randomized studies(MINORS)scale were used to assess the risk bias of included studies(randomized controlled trials and controlled trials). The published biases of included studies were assessed with funnel plot. Meta-analysis was performed with Review Manager 5.3.

RESULTS: Seven eligible studies, including 478 children, were included, 250 cases in ortho-k group, 228 cases in control group. The Meta-analysis indicated that change in axial length of ortho-k group was significantly less than the control group \〖WMD=-0.31, 95%CI(-0.35, -0.26), P<0.001\〗. Five studies observed adverse effects which all included the effect of positive staining of corneal fluorescein. One study reported chalazion in one child. None of the studies reported severe adverse events.

CONCLUSION: The overall findings suggested that orthokeratology might slow the progression of myopia in children of Asia.